Theories of ageing: a current vision
M.L. Polo Luque, M.P. Martínez Ortega, M.P. Ruiz Torres

SUMMARY

  Present review summarises new evidences on the mechanisms responsible for ageing. Both, a genetic program and external influences seem to be involved in the process, and an analysis of them is performed. A better knowledge of ageing-related genes, including the best described in human beings, the WRN gene, and the description of telomerase importance in the prevention of telomer shortening, a marker of ageing, are contributing progressively to understand the genetic basis of senescence. On the other hand, the role of reactive oxygen species is generally accepted. These metabolites may induce a direct damage in cell structures, but also may stimulate collagen synthesis through cytokine modulation. Finally, it is also possible that the ageing-determining genetic program could be linked to changes in the expression of some endogenous antioxidant genes.

KEY WORDS

Ageing, reactive oxygen species, antioxidants.

Vol. 13 nº2-2002